This Kraak porcelain dish in a museum in Malacca was emblazoned with the V. Around , two events caused the growth of VOC trade to stall. In the first place, the highly profitable trade with Japan started to decline. The loss of the outpost on Formosa to Koxinga in the Siege of Fort Zeelandia and related internal turmoil in China where the Ming dynasty was being replaced with the Qing dynasty brought an end to the silk trade after The shogunate enacted a number of measures to limit the export of these precious metals, in the process limiting VOC opportunities for trade, and severely worsening the terms of trade. This caused a spike in the price of pepper, which enticed the English East India Company EIC to enter this market aggressively in the years after Previously, one of the tenets of the VOC pricing policy was to slightly over-supply the pepper market, so as to depress prices below the level where interlopers were encouraged to enter the market instead of striving for short-term profit maximisation. The wisdom of such a policy was illustrated when a fierce price war with the EIC ensued, as that company flooded the market with new supplies from India.
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The annual return of invested capital in the earlier period stood at approximately 6 percent; in the latter period, 3.
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This reflects the basic change in the VOC’s circumstances that had occurred:
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A problem that the VOC shared with other companies was the high mortality and morbidity rates among its employees.
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So suggests new research that tracked changes in two genes thought to help regulate brain growth, changes that appeared well after the rise of modern humans , years ago. That the defining feature of humans — our large brains — continued to evolve as recently as 5, years ago, and may be doing so today, promises to surprise the average person, if not biologists.
Lahn and colleagues examined two genes, named microcephalin and ASPM, that are connected to brain size. If those genes don’t work, babies are born with severely small brains, called microcephaly. Using DNA samples from ethnically diverse populations, they identified a collection of variations in each gene that occurred with unusually high frequency. In fact, the variations were so common they couldn’t be accidental mutations but instead were probably due to natural selection, where genetic changes that are favorable to a species quickly gain a foothold and begin to spread, the researchers report.
Lahn offers an analogy: Medieval monks would copy manuscripts and each copy would inevitably contain errors — accidental mutations. Years later, a ruler declares one of those copies the definitive manuscript, and a rush is on to make many copies of that version — so whatever changes from the original are in this presumed important copy become widely disseminated. Scientists attempt to date genetic changes by tracing back to such spread, using a statistical model that assumes genes have a certain mutation rate over time.
For the microcephalin gene, the variation arose about 37, years ago, about the time period when art, music and tool-making were emerging, Lahn said. For ASPM, the variation arose about 5, years ago, roughly correlating with the development of written language, spread of agriculture and development of cities, he said.